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There is no evidence of interactions with propranolol, flunarizine, pizotifen or alcohol.
Prolonged vasospastic reactions have been reported with ergotamine. As these effects may be additive, 24 hours should elapse before IMIGRAN can be taken following any ergotamine-containing preparation. Conversely, ergotamine-containing preparations should not be taken until 6 hours have elapsed following sumatriptan administration.
An interaction may occur between IMIGRAN and MAOIs and concomitant administration is contraindicated (see Contraindications).
There have been rare post-marketing reports describing patients with serotonin syndrome (including altered mental status, autonomic instability and neuromuscular abnormalities) following the use of SSRIs and sumatriptan. Serotonin syndrome has also been reported following concomitant treatment with triptans and SNRIs (see Precautions).
